PM330. A Proof-of-concept Phase IIa Trial on an Investigational New Drug for Psychostimulant Use Disorder Treatment

While decreasing trend in gender differences in alcohol use disorders was reported in Western countries, the change in Asian countries is unknown. This study aims to explore the shifts in gender difference in alcohol abuse (AA) and dependence (AD) in Korea. We compared the data from two nationwide community surveys to evaluate gender differences in lifetime AA and AD by Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV). Face-to-face interviews using the Composite International Diagnostic Interview (CIDI) were applied to all subjects in 2001 (n = 6,220) and 2011 (n = 6,022). Male-to-female ratio of odds was decreased from 6.41 (95% CI, 4.81–8.54) to 4.37 (95% CI, 3.35–5.71) for AA and from 3.75 (95% CI, 2.96–4.75) to 2.40 (95% CI, 1.80–3.19) for AD. Among those aged 18–29, gender gap even became statistically insignificant for AA (OR, 1.59; 95% CI, 0.97–2.63) and AD (OR, 1.18; 95% CI, 0.80–2.41) in 2011. Men generally showed decreased odds for AD (0.55; 95% CI, 0.45–0.67) and women aged 30–39 showed increased odds for AA (2.13; 95% CI 1.18– 3.84) in 2011 compared to 2001. Decreased AD in men and increased AA in women seem to contribute to the decrease of gender gap. Increased risk for AA in young women suggests needs for interventions.